Scientists Discover Why People with Diabetes Are at Higher Risk of Cancer

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Researchers have found that there is a risk of certain types of cancer for type 1 or type 2 diabetes.

According to the study to be performed at the ‘ American Chemical Society collapse 2019 National conference ‘, the DNA is more damaging when blood sugar levels are high when blood sugar is normal, healthy, and less often Found. Cancer risk.

John Termini, who demonstrated this work at the meeting, said, “for diabetics, there are 2.5 times more risk of cancers.” These cancers are ovary, breast, kidneys and others.

Scientists are suspicious of the hormonal regulating that the risk of cancer is high for diabetic patients.

“In people with type 2 diabetes, their insulin glucose is not effectively carried into cells,” explains Terini. “So pancreas makes more insulin, and they are called Hyperinsulinania. “

In addition to controlling glucose levels in the blood, insulin stimulates the growth of hormone cells, possibly leading to cancer. Also, most people with type 2 diabetes have overweight, and their extra fat tissue produces a higher level of adipose than those with healthy weight.
Terminini and his associates are known as addications in the form of DNA bases that have been chemically altered in the cell culture and the mice of diabetes.

Of course, they have discovered a DNA addiction known as N2-(1-carboxyl)-2 ‘-Deaxaguanozin, or CEdG, which occurs more in diabetic models than normal cells or rats.

“Due to high glucose levels, DNA can suppress addicts and their repair, which together cause genetic instability and cancer,” added termini.

The researchers also wanted molecular reasons for the correct unresolved of addicts by cells.

They have identified two proteins that appear to be involved: the transcription factor is the HIF1a and signalling protein mTORC1, both of which show low functionality in diabetes.

According to the Terminini, there are already a number of drugs that induce HIF1a or mTORC1. Researchers plan whether these drugs reduce the risk of cancer in diabetic animal samples and, if so, they test in human beings.

US researchers have found that DNA causes more damage when blood sugar levels are high compared to normal and healthy levels, and less often. Gives an answer.

The new study was presented at the 2019 National meeting and Exhibition of the American Chemical Society (ACS), one of the largest scientific conferences this year, which began on Monday in San Diego, California.

“For diabetics, it has long been known that some cancers have a 2.5 times greater risk,” says John Termini, who is in the City of Hope, a cancer and diabetes research and treatment center. These include ovary, breast and kidney cancers.

“As the diabetes continues to increase, the rate of cancer also increases,” Termini said.

Scientists are suspicious of the hormonal regulating that the risk of cancer is high for diabetic patients. “In people with type 2 diabetes, their insulin glucose is not effectively carried into cells,” explains Termini. “So pancreas makes more insulin, and they are called Hyperinsulinemia. “

In addition to controlling glucose levels in the blood, insulin stimulates the growth of hormone cells, possibly leading to cancer. Also, most people with type 2 diabetes have overweight, and their high fat tissue produces adipose levels higher than those of healthy weight. These hormones promote chronic inflammation, which is associated with cancer.

Termini believes that blood glucose levels found in diabetes can harm DNA, that the gene is unstable, which leads to cancer.

Termini and his associates are known as addictions in the form of DNA bases that have been chemically altered in the cell culture and the mice of diabetes. Of course, they have discovered a DNA addiction known as N2-(1-carboxyl)-2 ‘-Deaxaguanozin, or CEdG, which occurs more in diabetic models than normal cells or rats.

They have identified two proteins that appear to be involved: the transcription factor is the HIF1a and signaling protein mTORC1, both of which show low functionality in diabetes. HIF1a will activate several genes involved in the repair process.

According to the Termini, there are already a number of drugs that induce HIF1a or mTORC1. Researchers are planning whether these drugs reduce the risk of cancer in diabetic animal samples, so they are tested in human beings.

More than 9,500 exhibitions will be given at the ACS meeting on Thursday related to the theme “Chemistry and Water “.